PathPlus™ GPER1 / GPR30 Antibody (N-Terminus)
Référence LS-A4290-50
Conditionnement : 50ul
Marque : LSBio
Contactez votre distributeur local :
Téléphone : +1 850 650 7790
Overview
Antibody:
GPER1 / GPR30 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Application:
IHC, IHC-P, IF, WB
Reactivity:
Human
Format:
Unconjugated, Unmodified
Specifications
Description
G-protein coupled estrogen receptor 1 (GPER1) promotes neuritogenesis in developing hippocampal neurons. It plays a role in acute neuroprotection against NMDA-induced excitotoxic neuronal death and increases firing activity and intracellular calcium oscillations in luteinizing hormone-releasing hormone (LHRH) neurons. GPER1 inhibits mature adipocyte differentiation and lipid accumulation, and is involved in the recruitment of beta-arrestin 2 ARRB2 at the plasma membrane in epithelial cells. It also functions as a receptor for aldosterone, mediating rapid regulation of vascular contractibility through the PI3K/ERK signaling pathway. Finally, it is implicated in cancer progression. References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804
(2) Publication(s)
Target
Human GPER1 / GPR30
Synonyms
GPER1 | CMKRL2 | CEPR | FEG-1 | G-protein coupled receptor 30 | G protein-coupled receptor 30 | GPCR-Br | GPER | Heptahelix receptor | LERGU | LyGPR | MER | GPR30 | IL8-related receptor DRY12 | LERGU2 | Chemokine receptor-like 2 | DRY12 | Membrane estrogen receptor
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Synthetic 16 amino acid peptide from N-Terminus extracellular domain of human GPR30. Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Monkey, Marmoset (88%).
Epitope
N-Terminus
Specificity
Human GPR30. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Applications
- IHC
- IHC - Paraffin (20 µg/ml)
- Immunofluorescence
- Western blot
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee About GPER1 / GPR30
Q99527 NM_001505 NP_001496.1
Validation
Brain, Alzheimer's disease neurofibrillary tangle
Brain, Alzheimer's disease senile plaque
Brain, Parkinson's Lewy Body
Anti-GPR30 antibody IHC of human breast carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPER1 / GPR30 antibody IHC of human Breast, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPER1 / GPR30 antibody IHC of human Pancreas, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
tech@hexabiogen.com