General Info
Host: | Rabbit |
Applications: | WB/IHC |
Reactivity: | Human/Mouse |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-Myeloid leukemia factor 1 (130-210) is suitable for use in Western Blot and Immunohistochemistry research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Concentration: | 1 mg/mL |
Dilution Range: | WB 1:500-2000IHC-p 1:50-300 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Information
Gene Symbol: | MLF1 |
Gene ID: | 4291 |
Uniprot ID: | MLF1_HUMAN |
Immunogen Region: | 130-210 |
Specificity: | MLF1 Polyclonal Antibody detects endogenous levels of MLF1 protein. |
Immunogen: | Synthesized peptide derived from MLF1. at AA range: 130-210 |
Description
Tissue Specificity | Most abundant in testis, ovary, skeletal muscle, heart, kidney and colon. Low expression in spleen, thymus and peripheral blood leukocytes. |
Post Translational Modifications | Phosphorylation is required for binding to YWHAZ. |
Function | Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus. |
Protein Name | Myeloid Leukemia Factor 1Myelodysplasia-Myeloid Leukemia Factor 1 |
Cellular Localisation | CytoplasmNucleusCell ProjectionCiliumCytoskeletonCilium Basal BodyShuttles Between The Cytoplasm And Nucleus |
Alternative Antibody Names | Anti-Myeloid Leukemia Factor 1 antibodyAnti-Myelodysplasia-Myeloid Leukemia Factor 1 antibodyAnti-MLF1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance